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2009 (1) CD003026

Calcium supplements are associated with a higher incidence of gastrointestinal-related adverse events, described as constipation, abdominal cramping, bloating, upper gastrointestinal events, gastrointestinal disorders, digestive symptoms, and in some cases, severe diarrhea or abdominal pain (123)

A clinician can talk through what is known, what is unknown, and what is appropriate for you

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However, the potential for isothiocyanates to inhibit various isoforms of the cytochrome P450 (CYP) family of enzymes raises the potential for interactions with drugs that are CYP substrates (see Biological Activities)